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Reliability and Validity in Qualitative Research (Qualitative Research Methods)

Description:

Authors Jerome Kirk and Marc L. Miller define what is―and what is not―qualitative research. They suggest that the use of numbers in the process of recording and analyzing observations is less important than that the research should involve sustained interaction with the people being studied, in their own language and on their own turf. Following a chapter on objectivity, the authors discuss the role of reliability and validity and the problems that arise when these issues are neglected. They present a paradigm for the qualitative research process that makes it possible to pursue validity without neglecting reliability.


Editorial Reviews

About the Author

The immune system must respond rapidly and efficaciously to microbial infection, yet this response must avoid becoming pathogenic to the host. In this context, regulatory T cells (T regs; CD4+ CD25+, FoxP3 expressing T cells) play a central role in regulating adaptive immune responses to ensure that tolerance to host tissues is maintained. A case in point is that autoimmune disease develops in both humans and mice deficient in T regs. Conversely, depletion of T regs has been shown to augment the immune response to cancer. The regulatory action of T regs involves the cytokines IL-10 and TGF-?. Moreover, cell-to-cell contact appears to be required for the suppression of T cell proliferation in vitro. However, virtually nothing is known about the cellular specificity, stoichiometry, kinetics or location of immunoregulatory events in vivo. With recent advances in multi-photon microscopy, complex cellular interactions can now be studied directly in native tissues. Our approach is to use single-cell imaging to assess T reg impact on antigen presentation, T cell activation and effector function. We are currently developing two complementary mouse models for this purpose. With the first system we will investigate the role of T regs in the rejection or progression of implanted primary tumors. In the second model, we will examine the regulation of T cell responses during Listeria infection. Our hope is that comparing and contrasting T cell regulation in these systems will provide useful insight for how tolerance and immunity are governed. A secondary interest in the lab is to use biophysical data obtained by multi-photon microscopy to develop tissue level models for T cell regulation. The potential synergy between imaging and computational biology is tremendous i.e., computer simulations will guide experimental design, and in situ imaging will provide solid quantitative data for model refinement.

Details:

Reliability and Validity in Qualitative Research (Qualitative Research Methods)

Product ID: U0803924704
Condition: New

BHD1489

Price includes VAT & Import Duties
Type: Paperback
Availability: In Stock

Quantity:

|

Order today to get by 7-14 business days

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Imported From: United States

At BOLO, we work hard to ensure the products you receive are new, genuine, and sourced from reputable suppliers.

Every product in the BOLO catalogue is sourced through our Verified Global Supply Network of verified sellers, authorized distributors or directly from the manufacturer.

Each product undergoes thorough inspection and verification at our consolidation and fulfilment centers to ensure it meets our strict authenticity and quality standards before being shipped and delivered to you.

If you ever have concerns regarding the authenticity of a product purchased from us, please contact Bolo Support. We will review your inquiry promptly and, if necessary, provide documentation verifying authenticity or offer a suitable resolution.

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While we strive to display accurate information, variations in packaging, labeling, instructions, or formulation may occasionally occur due to regional differences or supplier updates. For detailed or manufacturer-specific information, please contact the brand directly or reach out to BOLO Support for assistance.

Unless otherwise stated, all prices displayed on the product page include applicable taxes and import duties.

BOLO operates in accordance with the laws and regulations of Bahrain. Any items found to be restricted or prohibited for sale within the Bahrain will be cancelled prior to shipment. We take proactive measures to ensure that only products permitted for sale in Bahrain are listed on our website.

All items are shipped by air, and any products classified as “Dangerous Goods (DG)” under IATA regulations will be removed from the order and cancelled.

All orders are processed manually, and we make every effort to process them promptly once confirmed. Products cancelled due to the above reasons will be permanently removed from listings across the website.

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Reliability and Validity in Qualitative Research (Qualitative Research Methods)

Product ID: U0803924704
Condition: New
Reliability and Validity in Qualitative Research (Qualitative Research Methods)-0
Type: Paperback

BHD1489

Price includes VAT & Import Duties
Availability: In Stock

Quantity:

|

Order today to get by 7-14 business days

Delivery fee of BHD 2. Free for orders above BHD 20.

Returns & Warranty policies

Imported From: United States

At BOLO, we work hard to ensure the products you receive are new, genuine, and sourced from reputable suppliers.

Every product in the BOLO catalogue is sourced through our Verified Global Supply Network of verified sellers, authorized distributors or directly from the manufacturer.

Each product undergoes thorough inspection and verification at our consolidation and fulfilment centers to ensure it meets our strict authenticity and quality standards before being shipped and delivered to you.

If you ever have concerns regarding the authenticity of a product purchased from us, please contact Bolo Support. We will review your inquiry promptly and, if necessary, provide documentation verifying authenticity or offer a suitable resolution.

Your trust is our top priority, and we are committed to maintaining transparency and integrity in every transaction.

While we strive to display accurate information, variations in packaging, labeling, instructions, or formulation may occasionally occur due to regional differences or supplier updates. For detailed or manufacturer-specific information, please contact the brand directly or reach out to BOLO Support for assistance.

Unless otherwise stated, all prices displayed on the product page include applicable taxes and import duties.

BOLO operates in accordance with the laws and regulations of Bahrain. Any items found to be restricted or prohibited for sale within the Bahrain will be cancelled prior to shipment. We take proactive measures to ensure that only products permitted for sale in Bahrain are listed on our website.

All items are shipped by air, and any products classified as “Dangerous Goods (DG)” under IATA regulations will be removed from the order and cancelled.

All orders are processed manually, and we make every effort to process them promptly once confirmed. Products cancelled due to the above reasons will be permanently removed from listings across the website.

Description:

Authors Jerome Kirk and Marc L. Miller define what is―and what is not―qualitative research. They suggest that the use of numbers in the process of recording and analyzing observations is less important than that the research should involve sustained interaction with the people being studied, in their own language and on their own turf. Following a chapter on objectivity, the authors discuss the role of reliability and validity and the problems that arise when these issues are neglected. They present a paradigm for the qualitative research process that makes it possible to pursue validity without neglecting reliability.


Editorial Reviews

About the Author

The immune system must respond rapidly and efficaciously to microbial infection, yet this response must avoid becoming pathogenic to the host. In this context, regulatory T cells (T regs; CD4+ CD25+, FoxP3 expressing T cells) play a central role in regulating adaptive immune responses to ensure that tolerance to host tissues is maintained. A case in point is that autoimmune disease develops in both humans and mice deficient in T regs. Conversely, depletion of T regs has been shown to augment the immune response to cancer. The regulatory action of T regs involves the cytokines IL-10 and TGF-?. Moreover, cell-to-cell contact appears to be required for the suppression of T cell proliferation in vitro. However, virtually nothing is known about the cellular specificity, stoichiometry, kinetics or location of immunoregulatory events in vivo. With recent advances in multi-photon microscopy, complex cellular interactions can now be studied directly in native tissues. Our approach is to use single-cell imaging to assess T reg impact on antigen presentation, T cell activation and effector function. We are currently developing two complementary mouse models for this purpose. With the first system we will investigate the role of T regs in the rejection or progression of implanted primary tumors. In the second model, we will examine the regulation of T cell responses during Listeria infection. Our hope is that comparing and contrasting T cell regulation in these systems will provide useful insight for how tolerance and immunity are governed. A secondary interest in the lab is to use biophysical data obtained by multi-photon microscopy to develop tissue level models for T cell regulation. The potential synergy between imaging and computational biology is tremendous i.e., computer simulations will guide experimental design, and in situ imaging will provide solid quantitative data for model refinement.

Details:

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